This post event report of the 12th DSCI Best Practices Meet summarises the two days of the event. In the wake of COVID-19, DSCI hosted the 12th Best Practices Meet (BPM) in fully virtual mode. The theme for this edition of BPM was ‘Radical Uncertainty’, and the conference focussed on security & business resiliency. Having been presented with an unprecedented situation this year, business models have been upended. Technology and security are in a state of flux, and companies are evolving, rather adapting fast. This has certainly put business resilience at test and under tremendous pressure. BPM 2020 delved upon how enterprises are planning their security architecture, what new paradigms are getting conceptualized, and the dramatic changes in the attack ecosystem and several similar themes. This report showcases the different formats of sessions, the respective takeaways, key highlights of event, link to session videos and more.